Reduced glutamate decarboxylase activity in rat islet β cells which survived streptozotocin-induced cytotoxicity
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چکیده
منابع مشابه
Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat
Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabe...
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The present studies were carried out to characterize the cAMP-phosphodiesterase enzyme (PDE) in luteal cells recovered from pseudopregnant rats with streptozotocin-induced diabetes. A significant increase in the specific activity of the enzyme was detected in luteal cells from diabetic rats (Group D) with respect to control rats (Group C). This increase could not be prevented by insulin therapy...
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Background and Objective: Chronic diabetes mellitus (DM) leads to cardiovascular dysfunction. Diosgenin is a natural steroidal saponin with cardiovascular protective potential. In this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats (n = 28) were ...
متن کاملImmunohistochemical localization of glutamate decarboxylase in rat cerebellum.
Glutamate decarboxylase (L-glutamate l-carboxylase; EC 4.1.1.15), the enzyme in brain that forms gamma-aminobutyric acid, was made visible on sections of rat cerebellum by use of rabbit antiserum to purified mouse-brain glutamate decarboxylase. Cerebellar sections obtained from rats that were perfused with 4% paraformaldehyde were treated with antiserum against the enzyme or with serum from uni...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1993
ISSN: 0014-5793
DOI: 10.1016/0014-5793(93)80130-m